Program M is named after mulheres and mujeres, the words for women in Portuguese and Spanish. It was launched in 2006 as a companion to Program H (named for homens and hombres, or men), which encourages critical reflection among young men about rigid gender norms. Building on the experiences of Program H, Program M was developed to work specifically with young women, ages 15 to 24, and seeks to promote their health and empowerment through similar critical reflections about gender, rights, and health. Field-tested in Brazil, Jamaica, Mexico, and Nicaragua, it has since been adapted for use in other countries including India, Tanzania, Peru, and the Balkans. The Program M methodology combines educational workshops with youth-led community campaigns that work to promote gender-equitable attitudes among young women and improve their agency in interpersonal relationships. Organizers can choose from some 33 validated Program M activities to customize the program for the needs of their communities. These activities address a variety of topics, ranging from gender identity to sexual and reproductive health and rights, empowerment in interpersonal relationships, and motherhood and caregiving. Organizers can also consult the Program HMD Toolkit, an abbreviated manual that that includes recommendations for the implementation of Program M’s key activities. To complement the group education sessions, Promundo offers a conversation-starting, no-words video Once Upon a Girl, which tells the story of a girl who questions the gender norms around her, and how they influence the way she thinks and acts. Evaluation studies on Program M in Brazil and India, using items from the Gender Equitable Men (GEM) scale, a validated attitude scale that has been adapted and applied in more than 20 settings, along with other attitude and self-efficacy indicators, found that women who participate in the program experience increased communication with partners about sexual health, increased self-efficacy in interpersonal relationships, decreased drug use, and increased condom use by partners.